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Regulation of herpes simplex virus gene expression
1Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. weirj@cber.fda.gov
Gene
|June 22, 2001
Summary
Herpes simplex virus 1 (HSV-1) gene expression is tightly controlled by sequential regulation. Recent findings reveal new viral protein functions and highlight transcriptional, post-transcriptional, and host-interaction mechanisms.
Area of Science:
- Virology
- Molecular Biology
- Genetics
Background:
- Herpes simplex virus 1 (HSV-1) exhibits tightly regulated, sequential gene expression.
- Decades of research have focused on elucidating the regulatory mechanisms governing HSV-1 gene expression.
Purpose of the Study:
- To review recent findings on the regulation of HSV-1 gene expression during productive infection.
- To highlight newly identified functions of viral regulatory proteins.
- To examine the interplay between viral and host cell functions.
Main Methods:
- Review of recent scientific literature on HSV-1 gene expression.
- Analysis of findings related to transcriptional and post-transcriptional regulation.
- Examination of host-virus interactions.
Main Results:
- Several aspects of HSV-1 gene expression regulation are now better understood.
- New functions have been attributed to known viral regulatory proteins.
- Viral gene expression is controlled by both transcriptional and post-transcriptional mechanisms.
- HSV-1 actively manipulates host cell functions for its own benefit.
Conclusions:
- Understanding HSV-1 gene expression requires knowledge of viral regulatory proteins and host interactions.
- Future research should focus on temporal regulation mechanisms and virus-specific cell type interactions.
- Complete understanding necessitates investigating how HSV-1 diverts host functions.