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Salmonella pathogenicity islands encoding type III secretion systems
1Lehrstuhl für Bakteriologie, Max von Pettenkofer-Institut, LMU München, Germany.
Microbes and Infection
|June 22, 2001
Abstract:
Salmonella enterica harbours two Salmonella pathogenicity islands (SPIs) each encoding a type III secretion system for virulence proteins. SPI1 is required for invasion, while systemic infections and intracellular accumulation of Salmonella are dependent on SPI2 function. This review will describe and compare the genetic organisation, evolution, regulation and molecular functions of SPI1 and SPI2.