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Bk virus: a clinical review.

M D Reploeg1, G A Storch, D B Clifford

  • 1Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. reploegm@medicine.wustl.edu

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 22, 2001
PubMed
Summary

BK virus, a JC virus relative, is reviewed for its role in disease, particularly in immunosuppressed patients. While often present permissively, it

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Area of Science:

  • Virology
  • Immunology
  • Pathology

Background:

  • BK virus is a polyomavirus related to JC virus, the cause of progressive multifocal leukoencephalopathy (PML).
  • BK virus has been implicated in diseases affecting various organs, including the kidney, lung, eye, liver, and brain.
  • The virus has also been detected in neoplastic tissues.

Purpose of the Study:

  • To review the clinical literature concerning BK virus.
  • To elucidate the role of BK virus in various disease states, especially in immunocompromised individuals.
  • To clarify the pathophysiology of BK virus-associated conditions.

Main Methods:

  • Literature review of clinically oriented studies on BK virus.
  • Analysis of proposed sites of BK virus-associated disease.
  • Evaluation of evidence linking BK virus to specific pathologies.

Main Results:

  • BK virus is frequently found permissively in diseased tissues of immunosuppressed patients.
  • Strong evidence links BK virus to hemorrhagic cystitis and nephritis, particularly in transplant recipients.
  • New sensitive detection techniques aid in understanding BK virus pathophysiology.

Conclusions:

  • BK virus is often a permissive bystander rather than a direct cause of disease, except in specific cases like hemorrhagic cystitis and nephritis.
  • Further evaluation of clinical and pathological presentations is crucial for understanding BK virus-associated pathophysiology.
  • Advancements in detection methods facilitate a clearer understanding of BK virus's role in human disease.

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