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Urinary findings in asymptomatic subjects with spina bifida treated with intermittent catheterization

K Szucs1, K M O'Neil, H Faden

  • 1Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA.

The Pediatric Infectious Disease Journal
|June 23, 2001
PubMed

Insights

Asymptomatic children with spina bifida often show abnormal urine findings like bacteriuria and pyuria. Elevated interleukin-8 suggests these indicate low-grade infection, not just colonization.

Area of Science:

  • Pediatrics
  • Urology
  • Infectious Diseases

Background:

  • Spina bifida is a congenital condition that can affect urinary tract health.
  • Asymptomatic bacteriuria in children requires careful evaluation to distinguish infection from colonization.

Purpose of the Study:

  • To investigate the prevalence of urinary abnormalities in asymptomatic children with spina bifida.
  • To assess the role of interleukin-8 (IL-8) in differentiating infection from colonization in these patients.

Main Methods:

  • Analysis of urine samples from 43 asymptomatic children diagnosed with spina bifida.
  • Microbiological examination for bacteriuria and pyuria.
  • Quantification of interleukin-8 levels in urine.

Main Results:

  • 81% of urines exhibited abnormalities: 51% had both bacteriuria and pyuria, 26% had bacteriuria alone, and 5% had pyuria alone.
  • Elevated interleukin-8 levels were detected in 54% of abnormal urine samples.
  • The co-occurrence of pyuria and elevated IL-8 suggests an infectious process.

Conclusions:

  • Asymptomatic bacteriuria in children with spina bifida is common and frequently associated with pyuria.
  • Elevated interleukin-8 levels in conjunction with pyuria indicate a low-grade urinary tract infection rather than simple bacterial colonization.

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