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Skin reactions to inhaled corticosteroids
1Department of Occupational and Environmental Dermatology, Malmö University Hospital, Sweden. marlene.isaksson@derm.mas.lu.se
Drug Safety
|June 23, 2001
Summary
Contact allergy to inhaled corticosteroids is rare, with only one reported case. However, local application can cause allergic reactions and adverse effects in the nose and mouth.
Area of Science:
- Dermatology
- Allergology
- Pulmonology
Background:
- Inhaled corticosteroids (ICS) have been used since the 1970s for asthma and rhinitis.
- Limited research exists on contact allergy to ICS, with only one documented case.
Purpose of the Study:
- To review the literature on contact allergy and adverse effects of corticosteroids used locally in the nose and lungs.
Main Methods:
- Literature review of case reports and studies on inhaled and nasal corticosteroids.
Main Results:
- Only one case of contact allergy to budesonide and tixocortol pivalate was identified.
- Local application of corticosteroids can cause allergic mucosal and skin symptoms.
- Adverse effects include nasal congestion, burning, dryness, erythema, edema, cough, and in rare cases, nasal septum perforation.
- Systemic reactions like eczematous lesions and urticaria have been reported.
Conclusions:
- Contact allergy to inhaled corticosteroids is uncommon.
- Local adverse effects and allergic reactions are more frequently reported with topical corticosteroid use in the nose and lungs.