Enzyme biosensor for studying therapeutics of Alzheimer's disease

¹Department of Chemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, PR China. chlenigk@ust.hk

|June 23, 2001

Abstract:

An electrochemical method for the investigation and comparison of anti-Alzheimer medications that is based on the inhibition of the acetylcholinesterase is presented. The developed amperometric biosensor determines the in-vitro inhibition of the acetylcholinesterase that is co-immobilized with choline oxidase on the working electrode surface of a three-electrode system using gel entrapment. The sensor has been applied to determine the IC50 values of two known and one newly developed Alzheimer remedy. A simultaneous measurement with the photometric standard method shows the applicability of our method for fast drug screening.

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Abstract:

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