Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recombinant food allergens.

A R Lorenz1, S Scheurer, D Haustein

  • 1Department of Allergology, Paul-Ehrlich-Institut, Langen, Germany.

Journal of Chromatography. B, Biomedical Sciences and Applications
|June 23, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mass Spectrometry Detects Api m 10 in Venom Immunotherapy Products With Suspected Absence of Api m 10.

Journal of investigational allergology & clinical immunology·2025
Same author

A European-Japanese study on peach allergy: IgE to Pru p 7 associates with severity.

Allergy·2023
Same author

Peach extract induces systemic and local immune responses in an experimental food allergy model.

Scientific reports·2023
Same author

Validation of an ELISA method for quantification of the major Timothy grass pollen allergen Phl p 5a (BSP090).

Pharmeuropa bio & scientific notes·2022
Same author

Allergen Immunotherapy (AIT) in children: a vulnerable population with its own rights and legislation - summary of EMA-initiated multi-stakeholder meeting on Allergen Immunotherapy (AIT) for children, held at Paul-Ehrlich-Institut, Langen, Germany, 16.1.2019.

Clinical and translational allergy·2020
Same author

Allergen manufacturing and quality aspects for allergen immunotherapy in Europe and the United States: An analysis from the EAACI AIT Guidelines Project.

Allergy·2017

Recombinant food allergens offer improved diagnostics and therapeutics for food allergies. This review details their production, characteristics, and applications in allergy research and treatment.

Area of Science:

  • Food allergy research
  • Protein biochemistry
  • Immunology

Background:

  • Food allergies are triggered by allergenic (glyco)proteins, causing severe hypersensitivity.
  • Current diagnostic and therapeutic approaches face challenges.
  • Recombinant allergens provide standardized, high-quality tools.

Purpose of the Study:

  • To review the production and characteristics of over 40 recombinant food allergens.
  • To compare IgE-binding properties of recombinant vs. natural allergens.
  • To explore applications in diagnostics, therapeutics, and epitope mapping.

Main Methods:

  • Literature review of recombinant food allergen production strategies.
  • Analysis of characterized recombinant allergen properties.

Related Experiment Videos

  • Comparison of IgE-binding affinities and epitope profiles.

    • Main Results:

    • Over 40 recombinant food allergens have been successfully produced.
    • Recombinant allergens exhibit comparable IgE-binding to natural forms.
    • Hypoallergenic mutants and diagnostic tools have been developed.

    Conclusions:

    • Recombinant food allergens are valuable for allergy diagnosis and investigation.
    • Therapeutic strategies using hypoallergenic variants show promise.
    • Further research can refine allergen characterization and application.