Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left ventricular dysfunction after long-term right ventricular apical pacing in the young.

M V Tantengco1, R L Thomas, P P Karpawich

  • 1Division of Cardiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201, USA. mtanteng@dmc.org

Journal of the American College of Cardiology
|June 23, 2001
PubMed
Summary

Long-term right ventricular (RV) apical pacing in young patients impairs global left ventricular (LV) function, as shown by reduced fractional area of change (FAC) and increased myocardial performance index (MPI). Alternative pacing sites are recommended for pediatric patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IDF diabetes Atlas: A worldwide review of studies utilizing retinal photography to screen for diabetic retinopathy from 2017 to 2024 inclusive.

Diabetes research and clinical practice·2025
Same author

Trends in certifications of overall vision impairment and that due to diabetic retinopathy/maculopathy in England and Wales, 2009/2010 to 2019/2020: a retrospective database analysis.

BMJ open·2025
Same author

IDF Diabetes Atlas: A review of studies utilising retinal photography on the global prevalence of diabetes related retinopathy between 2015 and 2018.

Diabetes research and clinical practice·2019
Same author

Properties and Function of the Flexor Hallucis Capsularis Interphalangeus Tendon.

Clinical anatomy (New York, N.Y.)·2019
Same author

Acute shoulder injuries: A clinical review of diagnosis and management in the deployed Naval environment.

Journal of the Royal Naval Medical Service·2018
Same author

Cancer survivors' concealment or disclosure of diagnosis: Implications for return to work.

Work (Reading, Mass.)·2015

Area of Science:

  • Cardiology
  • Pediatric Electrophysiology
  • Echocardiography

Background:

  • Short-term right ventricular (RV) apical pacing is linked to reduced left ventricular (LV) pump function and relaxation due to asynchronous contraction.
  • The long-term impact of RV apical pacing on global LV function in young individuals is not well understood.

Purpose of the Study:

  • To evaluate the long-term effects of RV apical pacing on global LV function in pediatric patients.
  • To compare LV function in young patients with long-term RV apical pacing against age- and body surface area-matched controls.

Main Methods:

  • Assessed global LV function in 24 RV-apex-paced patients (1-19 years follow-up) using echocardiography-derived fractional area of change (FAC) and Doppler index of myocardial performance (MPI).
  • Compared data from 24 RV-paced patients (mean follow-up 9.5 years) with 33 age- and BSA-matched controls.

Related Experiment Videos

  • Utilized multiple linear regression to identify patient variables influencing LV function indexes.

    • Main Results:

    • Long-term RV apical pacing (median follow-up 10 years) resulted in significantly impaired LV systolic and diastolic function compared to controls (FAC: 52% vs. 60%, p < 0.01; MPI: 0.46 vs. 0.34, p < 0.01).
    • Paced QRS duration and patient age were significant predictors of global LV contraction (R2 = 0.4, p < 0.05).

    Conclusions:

    • Long-term RV apical pacing in young patients leads to impaired global LV function.
    • Exploring alternative ventricular pacing sites that mimic biventricular activation is crucial for preserving cardiac function in pediatric patients requiring long-term pacing.