Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurodevelopmental outcome in meningococcal disease: a case-control study.

J M Fellick1, J A Sills, O Marzouk

  • 1Institute of Child Health, Royal Liverpool Children's Hospital NHS Trust, Eaton Road, Liverpool L12 2AP, UK. jfellick@liv.ac.uk

Archives of Disease in Childhood
|June 23, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A dust-obscured massive maximum-starburst galaxy at a redshift of 6.34.

Nature·2013
Same author

A Study of the Distribution of Rheumatic Infection in Children in Birmingham.

Archives of disease in childhood·2010
Same author

The Effect of Variation of the Diet in Rheumatic Children.

Archives of disease in childhood·2010
Same author

A Case of Coarctation of the Aorta.

Archives of disease in childhood·2010
Same author

THE CLINICAL USE OF INSULIN.

British medical journal·2010
Same author

A Review of the Later Results of Insulin Treatment.

British medical journal·2010

Meningococcal infection survivors often show no gross neurological deficits but exhibit significant impairments in coordination, cognition, and behavior on objective testing. Long-term neurodevelopmental outcomes require careful assessment.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pediatrics

Background:

  • Meningococcal disease can have severe consequences.
  • Long-term neurodevelopmental outcomes in survivors are not fully understood.

Purpose of the Study:

  • To determine the long-term neurodevelopmental outcome in individuals who survived meningococcal infection.
  • To assess neurological function, coordination, cognition, behavior, and hearing in survivors.

Main Methods:

  • A cohort of 152 meningococcal disease cases (139 survivors) recruited between 1988-1990.
  • 115 survivors were evaluated between 1998-1999, compared with 115 age- and sex-matched controls.
  • Standardized measures assessed neurological function, coordination, cognition, behavior, and hearing.

Related Experiment Videos

Main Results:

  • One survivor had spastic quadriplegia; others had normal gross neurological exams.
  • Five survivors had significant hearing loss compared to no controls.
  • Survivors performed significantly worse than controls in coordination, cognition, and behavior, with four major impairments.

Conclusions:

  • Most meningococcal survivors do not present with gross neurological deficits.
  • Objective assessments reveal significant detriments in motor function, cognitive ability, and behavior among survivors.
  • Meningococcal infection can lead to subtle but significant long-term neurodevelopmental challenges.