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Related Experiment Videos

Neurodevelopmental outcome in meningococcal disease: a case-control study.

J M Fellick1, J A Sills, O Marzouk

  • 1Institute of Child Health, Royal Liverpool Children's Hospital NHS Trust, Eaton Road, Liverpool L12 2AP, UK. jfellick@liv.ac.uk

Archives of Disease in Childhood
|June 23, 2001
PubMed
Summary

Meningococcal infection survivors often show no gross neurological deficits but exhibit significant impairments in coordination, cognition, and behavior on objective testing. Long-term neurodevelopmental outcomes require careful assessment.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Pediatrics

Background:

  • Meningococcal disease can have severe consequences.
  • Long-term neurodevelopmental outcomes in survivors are not fully understood.

Purpose of the Study:

  • To determine the long-term neurodevelopmental outcome in individuals who survived meningococcal infection.
  • To assess neurological function, coordination, cognition, behavior, and hearing in survivors.

Main Methods:

  • A cohort of 152 meningococcal disease cases (139 survivors) recruited between 1988-1990.
  • 115 survivors were evaluated between 1998-1999, compared with 115 age- and sex-matched controls.
  • Standardized measures assessed neurological function, coordination, cognition, behavior, and hearing.

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Main Results:

  • One survivor had spastic quadriplegia; others had normal gross neurological exams.
  • Five survivors had significant hearing loss compared to no controls.
  • Survivors performed significantly worse than controls in coordination, cognition, and behavior, with four major impairments.

Conclusions:

  • Most meningococcal survivors do not present with gross neurological deficits.
  • Objective assessments reveal significant detriments in motor function, cognitive ability, and behavior among survivors.
  • Meningococcal infection can lead to subtle but significant long-term neurodevelopmental challenges.