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Management of sickle cell priapism with etilefrine
A D Gbadoé1, Y Atakouma, K Kusiaku
1Division of Infectiology and Onco-hematology, Department of Pediatrics, University of Lomé, BP 8881, Lomé-Togo. adgbadoe@tg.refer.org
Insights
Etilefrine effectively treated acute sickle cell priapism in children via injection. Oral etilefrine also resolved stuttering priapism, showing greater efficacy in childhood cases compared to adults.
Area of Science:
- Pediatric Hematology
- Urology
- Pharmacology
Background:
- Sickle cell disease (SCD) is a genetic blood disorder.
- Priapism, a prolonged erection, is a painful complication of SCD.
- Effective treatments for pediatric priapism are crucial.
Purpose of the Study:
- To evaluate the efficacy of etilefrine in treating childhood sickle cell priapism.
- To compare the effectiveness of etilefrine in children versus adults.
Main Methods:
- Intracavernous injections of etilefrine for acute priapism.
- Oral etilefrine for stuttering priapism.
- Clinical observation and follow-up for treatment outcomes.
Main Results:
- Intracavernous etilefrine injections were effective in seven pediatric patients with acute sickle cell priapism.
- Oral etilefrine resolved stuttering priapism in five children within one to seven months.
- Etilefrine demonstrated higher effectiveness in children than previously reported in adults.
Conclusions:
- Etilefrine is a promising therapeutic agent for pediatric sickle cell priapism.
- Both acute and stuttering forms of priapism in children show positive response to etilefrine.
- Further research into etilefrine's pediatric application is warranted.
Abstract:
Intracavernous injections of etilefrine were effective in seven children with acute sickle cell priapism, and stuttering priapism resolved in five children after one to seven months of oral etilefrine. Compared with our previous reports in adults, etilefrine appears to be more effective in childhood.