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Perforator-based flap in rats: a new experimental model.

H S Okşar1, O K Coşkunfirat, H E Ozgentaş

  • 1Department of Plastic and Reconstructive Surgery, Akdeniz University School of Medicine, Antalya, Turkey. seckin_oksar@yahoo.com

Plastic and Reconstructive Surgery
|June 23, 2001
PubMed
Summary

Researchers developed a reliable rat model for perforator-based flaps, a popular surgical technique. This new animal model demonstrated significant flap survival, paving the way for further research into these advanced reconstructive methods.

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Area of Science:

  • Plastic Surgery
  • Microsurgery
  • Experimental Surgery

Background:

  • Perforator-based flaps are increasingly used in plastic surgery but lack established animal research models.
  • Clinical success has outpaced preclinical research, highlighting a need for reliable experimental systems.

Purpose of the Study:

  • To develop and validate a novel rat model for studying perforator-based flaps.
  • To evaluate the survival characteristics and reliability of this new flap model.

Main Methods:

  • A perforator-based abdominal skin flap was created in rats, based on the superior deep epigastric artery perforator.
  • Two control groups were established: one with a flap elevated on a subcutaneous pedicle without perforators, and another with a random-pattern flap.
  • Flap survival, microangiography, and histological studies were performed one week post-surgery.

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Main Results:

  • The perforator-based flap group showed significant survival rates (74-83%).
  • Control groups exhibited minimal (random-pattern: 29-44%) or no (subcutaneous pedicle: 0%) flap survival.
  • A predictable pattern of necrosis was observed in the model, with statistically significant differences between groups (p < 0.001).

Conclusions:

  • A single musculocutaneous perforator vessel can support a large area of abdominal skin survival in rats.
  • The developed perforator-based flap model is reliable, easily elevated, and suitable for future flap research.