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[Metallic elements in tissues surrounding internal rigid fixation (IRF) devices].

C Bertoldi1, D Zaffe, P Bellini

  • 1Dipartimento delle Discipline Chirurgiche e delle Emergenze, Sezione di Clinica Odontoiatrica, Università degli Studi di Modena e Reggio Emilia, Italy.

Minerva Stomatologica
|June 23, 2001
PubMed
Summary

Metal particles from orthopedic implants can diffuse into surrounding tissues, causing inflammation. Titanium and aluminum release from internal rigid fixation (IRF) devices warrants further investigation for cellular effects.

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Area of Science:

  • Biomaterials science
  • Orthopedic surgery
  • Toxicology

Context:

  • Internal rigid fixation (IRF) devices utilize various alloys for bone fracture stabilization.
  • Metal elements from these alloys can be detected in local tissues and organs.
  • Understanding metal particle diffusion and tissue response is crucial for patient safety.

Purpose:

  • To analyze tissues surrounding IRF devices.
  • To investigate the morphology of released metal particles.
  • To assess metallic element diffusion and adjacent tissue behavior.

Summary:

  • Biopsies from 18 patients with IRF devices were analyzed using microscopy and X-ray microprobe analysis.
  • Metal particles (Chromium, Iron, Aluminium, Titanium) were found to diffuse into tissues and undergo cellular uptake.

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  • Titanium diffusion was evident in fibrous tissue, while Aluminium accumulated persistently.

    • Impact:

    • Metallosis and phlogosis are correlated, with metal elements contributing to inflammation.
    • The study highlights the inflammatory potential of various metals released from IRF devices.
    • Further research is needed on the cellular effects of Titanium release, given its significant diffusion.