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Transcription therapy for cancer
1Department of Human Genetics and Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, 1275 York Avenue, New York, NY 10021, USA.
Oncogene
|June 23, 2001
Summary
Targeting cancer
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Cancer arises from specific gene expression profiles and molecular lesions.
- Traditional therapies target oncogenic biochemical activity.
- An alternative is to block transcriptional consequences of oncogenic activity.
Purpose of the Study:
- To review the potential of transcription-based therapies for cancer.
- To explore the feasibility of antagonizing key transcriptional events in cancer pathogenesis.
Main Methods:
- High-throughput gene expression analysis.
- Detailed understanding of gene regulatory regions and transcription factors.
- Pharmacological and biochemical modulation of gene expression.
- Direct antagonism of oncogenic transcription factor activity.
- In vivo validation in animal cancer models.
Main Results:
- Advances enable analysis and modulation of gene expression.
- Knowledge of transcription factors and regulatory regions is increasing.
- Potential for targeting transcriptional events in cancer is emerging.
Conclusions:
- Transcription therapy offers a novel approach to cancer treatment.
- This strategy targets the downstream effects of oncogenic activity.
- Further research and validation in animal models are crucial for clinical application.