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Perfluorodecalin-induced intravitreal inflammation
J Singh1, K Ramaesh, S B Wharton
1Princess Alexandra Eye Pavilion, Chalmer's Street, Edinburgh, EH3 9HA, UK.
Objective:
To report an unusual case of intravitreal inflammation in a human eye caused by the presence of residual perfluorodecalin in a case of giant retinal tear and retinal detachment.
Methods:
The posterior capsule of the lens, which was infiltrated with deposits, was collected during surgery. The specimen was stained with hematoxylin and eosin, with periodic acid-Schiff, and for melanin. Part of it was examined with electron microscopy. Immunohistochemical staining was performed to demonstrate CD68 antigens, cytokeratin, and glial fibrillary acid protein.
Results:
Vacuolated macrophages and retinal pigment epithelial cells infiltrated the posterior capsule. Electron microscopy showed the presence of membrane-lined vacuoles within the macrophages. A monolayer of epithelial cells covered the cellular infiltration.
Conclusion:
Residual perfluorodecalin can induce an intraocular chronic macrophage response.