Cytotoxic cyclolignans related to podophyllotoxin

M Gordaliza¹, J M Miguel del Corral, M Angeles Castro

¹Departamento de Química Farmacéutica, Facultad de Farmacia, Campus Miguel de Unamuno, Universidad de Salamanca, Spain. milza@gugu.usal.es

Farmaco (Societa Chimica Italiana : 1989)

|June 26, 2001

Abstract:

The cyclolignan family of natural products includes compounds with important antineoplastic and antiviral properties such as podophyllotoxin and two of their semisynthetic derivatives, etoposide and teniposide. The latter are included in a wide variety of cancer chemotherapy protocols. Due to these biological activities, cyclolignans have been the objective of numerous studies focused to prepare better and safer anticancer drugs. Several cyclolignans related to podophyllotoxin have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28); some of them have antiviral and immunosuppressive activities.

Related Experiment Videos

Cytotoxic cyclolignans related to podophyllotoxin

Related Concept Videos

[High-risk drug use: epidemiological pattern through hair testing in the forensic context].

Synthetic approaches towards the marine alkyl purines.

Impact of inosine triphosphatase gene variants on the risk of anemia in HIV/hepatitis C virus-coinfected patients treated for chronic hepatitis C.

Cardenolides and diterpenes as a source of and model for positive ionotropic agents.

Synthesis and cytotoxic evaluation of 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate.

Cytotoxic-antineoplastic derivatives of prenyl-1,2-naphthohydroquinone.

Chemical and biochemical transformations of 5-ethoxycarbonyl-5-phenyl-2-isoxazolines.

Nasal administration of heparin-loaded microspheres based on poly(lactic acid).

New 8-substituted xanthiene derivatives as potent bronchodilators.

In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies.

Synthesis of 3-aryl-5-decapentyl-1,2,4-oxadiazoles possessing antiinflammatory and antitumor properties.

Syntheses, in vitro antibacterial and antifungal activities of a series of N-alkyl, 1,4-dithiines.

Carbazolyl-Substituted Benzoic Anhydrides as Efficient Triplet Harvesters for High-Brightness Blue Organic Light-Emitting Diodes.

Research progress in the ethnopharmacology, phytochemistry, pharmacology, quality control, and product development of Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou fruit pulp.

Aucubin as a multifunctional iridoid glycoside: Molecular pharmacology and therapeutic mechanisms supporting its potential as a drug discovery scaffold.

Synthesis, Biological Evaluation, and in Silico Studies of Novel Triazole- and Oxadiazole-Based Acetamides as Urease and α-Glucosidase Inhibitors.

Expulsion of nuclear DNA to the cytoplasm after viral entry: A mechanism for activation of the cGAS pathway.

Recent trends in synthetic approaches to α-amino ketones.

Related Experiment Videos

Cytotoxic cyclolignans related to podophyllotoxin

Abstract:

Related Concept Videos

Related Articles