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Updated: Oct 6, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Cytotoxic cyclolignans related to podophyllotoxin
M Gordaliza1, J M Miguel del Corral, M Angeles Castro
1Departamento de Química Farmacéutica, Facultad de Farmacia, Campus Miguel de Unamuno, Universidad de Salamanca, Spain. milza@gugu.usal.es
Abstract:
The cyclolignan family of natural products includes compounds with important antineoplastic and antiviral properties such as podophyllotoxin and two of their semisynthetic derivatives, etoposide and teniposide. The latter are included in a wide variety of cancer chemotherapy protocols. Due to these biological activities, cyclolignans have been the objective of numerous studies focused to prepare better and safer anticancer drugs. Several cyclolignans related to podophyllotoxin have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28); some of them have antiviral and immunosuppressive activities.
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