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Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair
1Laboratory of Molecular Genetics, Leiden Institute of Chemistry, Leiden University, The Netherlands. n.goosen@chem.leidenuniv.nl
Research in Microbiology
|June 26, 2001
Abstract:
Nucleotide excision repair in eubacteria is a process that repairs DNA damages by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites which have the characteristic signature of the family of ABC proteins and UvrB having one ATP binding site that is structurally related to that of helicases.