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Related Experiment Videos

Selective estrogen receptor modulators: from bench to bedside and back.

M D Whitaker1

  • 1Division of Endocrinology, Mayo Clinic, Scottsdale, AZ 85259, USA

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|June 26, 2001
PubMed
Summary

Selective estrogen receptor modulators (SERMs) offer viable treatment options for menopausal issues, impacting organs like bone and breast positively. These agents modify estrogen receptors, showing tissue-specific effects and varying clinical efficacy.

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Area of Science:

  • Pharmacology
  • Endocrinology
  • Gynecology

Background:

  • Selective estrogen receptor modulators (SERMs) have evolved significantly since the late 1960s.
  • By the late 1980s, SERMs became influential in clinical practice, offering targeted estrogenic effects.

Purpose of the Study:

  • To review the historical development of SERMs.
  • To assess the organ-level effects of SERMs based on current data.
  • To elucidate the mechanism of action of SERMs.

Main Methods:

  • Comprehensive review of pertinent medical literature.
  • Summarization of SERM effects on various end-organs.

Main Results:

  • SERMs demonstrate variable efficacy for menopausal symptoms, genitourinary effects, and positive impacts on serum lipids and bone density.

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  • SERMs show significant efficacy in breast cancer prevention, contrasting with estrogen's effects.
  • Potential disadvantages include exacerbation of menopausal symptoms and increased risk of venous thromboembolism.

    • Conclusions:

    • SERMs represent a valuable therapeutic option for managing diverse menopausal-related conditions.
    • Their tissue-specific actions, mediated by estrogen receptor modification, explain variable clinical outcomes.