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Chemical constituents from Lippia sidoides and cytotoxic activity
S M Costa1, T L Lemos, O D Pessoa
1Departamento de Química Orgânica e Inorgânica, Universidade Vale do Acaraú, CP 12200 60451-970 Fortaleza, Ceará, Brazil.
Journal of Natural Products
|June 26, 2001
Abstract:
Eleven known compounds and a new prenylated naphthoquinone, lippsidoquinone (13), were isolated from ethanol extracts of Lippia sidoides. Their structures were established by a combination of 1D and 2D NMR, IR, and EIMS spectral data analysis. The cytotoxic properties of compounds 3--13 were evaluated against HL60, SW1573, and CEM cell lines. Only tectol (6) and lippsidoquinone (13) exhibited significant activity against human leukemia cell lines HL60 and CEM.