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Trichophyton sensitivity in allergic and nonallergic asthma
Allergy
|June 26, 2001
Summary
Fungal infections, particularly Trichophyton, are linked to asthma, especially severe nonallergic asthma. Testing for dermatophyte sensitivity is recommended for these patients.
Area of Science:
- Allergology
- Dermatology
- Pulmonology
Background:
- Inhaled fungi are known asthma triggers, but dermatophyte sensitivity's role is less understood.
- Trichophyton allergy's causal link to asthma requires further investigation.
- This study explores Trichophyton sensitivity in asthma patients with tinea.
Purpose of the Study:
- To assess Trichophyton sensitivity in allergic and nonallergic asthma patients with tinea.
- To compare sensitivity rates across different patient groups and controls.
- To identify factors influencing Trichophyton sensitivity in asthma.
Main Methods:
- 86 subjects were divided into five groups: nonallergic asthma with tinea, allergic asthma with tinea, asthma without tinea, tinea without asthma, and healthy controls.
- Skin tests with standardized Trichophyton rubrum extracts and specific IgE measurements were performed.
- Microscopic evaluation and fungal cultures were used to diagnose dermatophyte infections.
Main Results:
- Higher skin test positivity rates to Trichophyton were observed in patients with tinea, regardless of asthma status.
- Nonallergic asthma patients with tinea showed a higher, though not statistically significant, rate of Trichophyton sensitivity and severe asthma.
- Fungal cultures confirmed T. rubrum as the most common dermatophyte in infected patients.
Conclusions:
- Fungal infection is a key factor in Trichophyton hypersensitivity, irrespective of asthma or allergy.
- Patients with severe, intrinsic asthma, particularly nonallergic cases with tinea, warrant evaluation for fungal infection and dermatophyte antigen sensitivity.
- Dermatophyte antigen testing may be crucial for managing severe asthma cases.
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