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Urate and arteriosclerosis in primary hyperparathyroidism.

J Westerdahl1, S Valdemarsson, P Lindblom

  • 1Departments of Surgery and Internal Medicine, Lund University Hospital, Lund, Sweden. johan.westerdahl@kir.lu.se

Clinical Endocrinology
|June 26, 2001
PubMed
Summary
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Elevated serum urate levels are an independent risk factor for arteriosclerotic disease in patients with primary hyperparathyroidism (pHPT). This metabolic abnormality may also be linked to increased glucose and triglyceride levels.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Primary hyperparathyroidism (pHPT) is associated with increased cardiovascular disease mortality.
  • A potential link between serum urate and cardiovascular disease has been proposed.
  • Metabolic derangements in pHPT may involve urate accumulation.

Purpose of the Study:

  • To investigate the metabolic arteriosclerotic risk profile in pHPT patients.
  • To specifically evaluate the role of serum urate in this risk profile.

Main Methods:

  • Retrospective analysis of 130 pHPT patients over 44 years old, before and 1 year post-surgery.
  • Assessment of biochemical markers for arteriosclerotic disease (AD) and renal function, including glomerular filtration rate (GFR).

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Main Results:

  • Patients with AD showed higher age, serum urate, triglyceride levels, and impaired renal function compared to those without AD.
  • Serum urate was identified as an independent risk factor for AD in pHPT (P < 0.01).
  • Urate levels correlated positively with male gender, fasting blood glucose, and triglyceride levels.

Conclusions:

  • Serum urate is an independent risk factor for arteriosclerotic disease in primary hyperparathyroidism.
  • Elevated urate may indicate an associated metabolic disorder involving increased glucose and triglyceride levels.