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Updated: Aug 10, 2026
09:18
Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
Published on: February 24, 2023
Pathogenesis of psoriatic arthritis
1Department of Rheumatology, St Vincent's University Hospital, Elm Park, Dublin, Ireland.
Clinical and Experimental Dermatology
|June 26, 2001
Summary
Psoriasis and psoriatic arthritis remain poorly understood, despite over a century of recognition. This review explores immunogenetics, infection, autoimmunity, and other factors to uncover shared mechanisms driving these inflammatory conditions.
Area of Science:
- Immunology
- Dermatology
- Rheumatology
Background:
- Psoriasis and psoriatic arthritis are chronic inflammatory conditions recognized for over a century.
- The precise link and pathogenesis connecting skin/nail psoriasis with joint arthritis remain unexplained.
- Recent advancements in understanding skin and joint inflammation offer potential insights.
Purpose of the Study:
- To explore shared mechanisms underlying psoriasis and psoriatic arthritis.
- To highlight under-referenced aspects of disease pathogenesis.
- To integrate knowledge from immunogenetics, infection, autoimmunity, vascular morphology, trauma, and the nervous system.
Main Methods:
- Literature review and synthesis of existing research.
- Exploration of specific etiological factors: immunogenetics, infection, autoimmunity.
- Investigation of contributing factors: vascular morphology/angiogenesis, trauma, nervous system involvement.
Main Results:
- Identified common threads in inflammation mechanisms for skin and joints.
- Highlighted the potential roles of immunogenetics and autoimmunity in disease development.
- Underscored the significance of vascular changes, trauma, and neural factors.
Conclusions:
- A comprehensive understanding of psoriasis and psoriatic arthritis requires integrating multiple etiological factors.
- Further research into the interplay of immunogenetics, autoimmunity, and environmental triggers is crucial.
- Exploring under-referenced aspects like vascular, neural, and trauma-related pathways may unlock new therapeutic targets.
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