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An 8-year experience with routine SL mix patch testing supplemented with Compositae mix in Denmark
E Paulsen1, K E Andersen, B M Hausen
1Department of Dermatology, Odense University Hospital, DK-5000 Odense C, Denmark.
Contact Dermatitis
|June 26, 2001
Summary
Sesquiterpene lactone (SL) mix and Compositae mix (CM) patch testing identified Compositae sensitivity in 4.3% of patients. Combining SL mix and CM significantly improved detection rates for allergic contact dermatitis.
Area of Science:
- Dermatology
- Allergology
- Contact Dermatitis
Background:
- Compositae-sensitive allergic contact dermatitis is common.
- Patch testing is crucial for diagnosis.
- Sesquiterpene lactone (SL) mix and Compositae mix (CM) are key allergens.
Purpose of the Study:
- To evaluate the efficacy of routine patch testing with SL mix and CM.
- To determine the detection rate of Compositae sensitivity.
- To assess the clinical relevance and safety of patch testing.
Main Methods:
- Retrospective analysis of 4386 patients over 8 years.
- Patch testing using SL mix, CM, and other Compositae extracts.
- Evaluation of reaction relevance, sensitization, and co-allergies.
Main Results:
- 4.3% of patients showed Compositae sensitivity (190/4386).
- SL mix detected 65%, CM detected 87%; combined detection rate was 93%.
- 83% of reactions were clinically relevant; 22% suspected occupational dermatitis.
Conclusions:
- SL mix is effective for screening Compositae sensitivity.
- Supplementing with CM testing enhances diagnostic yield.
- Patch testing with these mixes is safe and effective for identifying allergic contact dermatitis.