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Fatty acid binding protein 2 and insulin resistance.

K C Chiu¹, L M Chuang, A Chu

¹Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA. kchiu@mednet.ucla.edu

European Journal of Clinical Investigation

|June 26, 2001

Summary

This summary is machine-generated.

The A54T polymorphism in the fatty acid binding protein 2 (FABP2) gene is linked to insulin resistance in Caucasians. This genetic variation independently influences insulin sensitivity, highlighting its role as a risk factor.

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Area of Science:

Genetics and Molecular Biology
Metabolic Diseases
Human Physiology

Background:

The A54T polymorphism of the fatty acid binding protein 2 (FABP2) gene has been associated with insulin resistance.
Previous findings were observed in nondiabetic Pima Indian populations.

Purpose of the Study:

To investigate the role of the FABP2 A54T polymorphism in insulin resistance.
To examine the association between FABP2 genotypes and measures of insulin sensitivity and beta-cell function in healthy Caucasians.

Main Methods:

Cross-sectional study of 71 healthy Caucasian subjects with normal glucose tolerance.
Genotyping using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Estimation of insulin sensitivity (e.g., %S, ISI(S)) and beta-cell function using established models.

Main Results:

Subjects with the AT/TT genotypes exhibited lower insulin sensitivity (%S, ISI(S)) compared to the AA genotype group (P < 0.05).
The FABP2 A54T polymorphism was identified as an independent, albeit modest, determinant of insulin sensitivity.
No significant differences in beta-cell function were observed between genotypic groups.

Conclusions:

The A54T polymorphism in the FABP2 gene is a risk factor for insulin resistance in a Caucasian population.
This genetic variant contributes to variations in insulin sensitivity.