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Increased microvessel density in malignant and borderline mammary phyllodes tumours
1Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Shatin, China. garytse@cuhk.edu.hk
Histopathology
|June 26, 2001
Summary
Microvessel density, a measure of tumour vascularity, significantly differs between benign and borderline phyllodes tumours. This finding suggests microvessel density can aid in evaluating phyllodes tumour histology.
Area of Science:
- Oncology
- Pathology
- Histology
Background:
- Tumour vascularity is a known prognostic indicator in breast carcinoma.
- The prognostic value of vascularity in phyllodes tumours remains unexplored.
Purpose of the Study:
- To investigate the correlation between intratumoral microvessel density and the histological grade of phyllodes tumours.
- To determine if microvessel density can serve as an objective histological parameter for phyllodes tumour evaluation.
Main Methods:
- Retrospective review of 40 phyllodes tumour cases.
- Histological grading based on stromal cellularity, overgrowth, cytological pleomorphism, mitotic count, and margin pattern (benign, borderline, malignant).
- Microvessel density quantification using CD31 staining.
Main Results:
- Benign (n=28), borderline (n=10), and malignant (n=2) phyllodes tumours were identified.
- Mean microvessel density was 13.1 for benign, 22.4 for borderline, and 29.6 for malignant tumours.
- A significant difference in microvessel density was observed between benign and borderline groups (P < 0.0001).
Conclusions:
- Stromal microvessel density shows a significant difference between benign and borderline phyllodes tumours.
- Microvessel density may serve as an additional objective histological parameter in phyllodes tumour assessment.
- Further studies with larger malignant case cohorts are needed for complete interpretation.