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Narcolepsy and other non-SAS hypersomnia in sleep breathing disorders clinic
K Banno1, T Shiomi, R Sasanabe
1The Third Department of Internal Medicine, Sleep Disorders Center, Aichi Medical University School of Medicine, Aichi, Japan. katsu@aichi-med-u.ac.jp
Psychiatry and Clinical Neurosciences
|June 26, 2001
Abstract:
Four of the 708 snorers (0.56%), referred to our sleep breathing disorders clinic for the past 2 years were diagnosed as having narcolepsy-cataplexy. Detecting HLA DRB1*1501/DQB1*0602 positive was informative for differentiating genuine narcolepsy from non-sleep apnea syndrome (non-SAS) hypersomnia in our clinic. A non-SAS obese boy, diagnosed as having essential hypersomnia syndrome, was found to be HLA DRB1*1502/DQB1*0601 positive. His hypocretin concentration was 206 pg/mL in the cerebrospinal fluid.