Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melatonin therapy for REM sleep behavior disorder.

N Takeuchi1, N Uchimura, Y Hashizume

  • 1Department of Neuropsychiatry, School of Medicine, Kurume University, Fukuoka, Japan. take1901@yahoo.co.jp

Psychiatry and Clinical Neurosciences
|June 26, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydroxyl radical production by H2O2 plus Cu,Zn-superoxide dismutase reflects the activity of free copper released from the oxidatively damaged enzyme.

The Journal of biological chemistry·1992
Same author

Effect of cilostazol, a cyclic AMP phosphodiesterase inhibitor, on the proliferation of rat aortic smooth muscle cells in culture.

Journal of cardiovascular pharmacology·1992
Same author

Inhibition of mite protease (Df-protease) with protease inhibitors.

Biochemistry international·1992
Same author

[Pharmacokinetic and clinical studies of cefprozil fine granules in children].

The Japanese journal of antibiotics·1992
Same author

[A case of primary alveolar hypoventilation syndrome with a good response to nocturnal low-flow oxygen inhalation and negative pressure ventilation].

Nihon Kyobu Shikkan Gakkai zasshi·1992
Same author

Microvasculature of normal and hydropic labyrinth.

Scanning microscopy·1992

Melatonin effectively treats Rapid Eye Movement Sleep Behavior Disorder (RBD) symptoms and improves polysomnography findings. This study confirms melatonin

Area of Science:

  • Neurology
  • Sleep Medicine
  • Pharmacology

Background:

  • Rapid Eye Movement Sleep Behavior Disorder (RBD) is a parasomnia characterized by dream-enacting behaviors during REM sleep.
  • Current treatments like clonazepam have limitations, prompting investigation into alternative therapies.

Purpose of the Study:

  • To reconfirm the efficacy of melatonin in treating symptoms of Rapid Eye Movement Sleep Behavior Disorder (RBD).
  • To assess the impact of melatonin on polysomnographic (PSG) findings in RBD patients.

Main Methods:

  • A study involving RBD patients treated with melatonin at dosages of 3-9 mg/day.
  • Polysomnography (PSG) was used to evaluate sleep and muscle atonia parameters.

Main Results:

Related Experiment Videos

  • Melatonin significantly ameliorated problematic sleep behaviors in RBD patients.
  • Treatment with melatonin also improved polysomnographic variables, specifically %tonic activity.
  • Efficacy was particularly noted in patients with diminished melatonin secretion.

    • Conclusions:

    • Melatonin is a confirmed effective treatment for Rapid Eye Movement Sleep Behavior Disorder (RBD) symptoms.
    • Melatonin shows promise, especially for RBD patients with low endogenous melatonin levels.
    • The precise mechanism of melatonin's action in RBD requires further investigation.