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Related Experiment Videos

Comparison of two platelet additive solutions.

P F van der Meer1, R N Pietersz, H W Reesink

  • 1Blood Bank North Holland, Amsterdam, The Netherlands. bnhams@hetnet.nl

Transfusion Medicine (Oxford, England)
|June 26, 2001
PubMed
Summary

Composol-PS and PAS-II platelet additive solutions both support 9-day storage of platelet concentrates. Composol-PS offers superior pH stability, indicating better buffering capacity for platelet storage.

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Area of Science:

  • Transfusion Medicine
  • Hematology
  • Biotechnology

Background:

  • Platelet additive solutions (PAS) are used to replace plasma for storing leukodepleted platelet concentrates.
  • Evaluating different PAS is crucial for optimizing platelet storage and quality.

Purpose of the Study:

  • To compare the efficacy of two platelet additive solutions, PAS-II and Composol-PS, for the storage of leukodepleted platelet concentrates.
  • To assess the impact of these solutions on platelet quality, particularly pH, over a 9-day storage period.

Main Methods:

  • A paired experimental design (n=10) was used to minimize donor variability.
  • Platelet concentrates were prepared from pooled buffy coats and stored with either PAS-II or Composol-PS.
  • Leukocyte reduction was achieved via prestorage filtration.

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  • pH and swirling effect were monitored throughout the 9-day storage period.

    • Main Results:

    • Both PAS-II and Composol-PS supported platelet storage for up to 9 days, with the presence of the swirling effect.
    • Composol-PS maintained a more constant pH (average 6.93 from day 2-7, 6.90 at day 9) compared to PAS-II (pH decreased from 6.97 at day 1 to 6.86 at day 9).

    Conclusions:

    • Both PAS-II and Composol-PS are suitable for storing pooled buffy coat-derived platelets for 9 days with good in vitro quality.
    • Composol-PS demonstrates a slightly better buffering capacity, resulting in a more stable pH during storage.