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Evolution of mammalian genome organization inferred from comparative gene mapping
W J Murphy1, R Stanyon, S J O'Brien
1Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702-1201, USA. murphywi@mail.ncifcrf.gov
Genome Biology
|June 26, 2001
Abstract:
Comparative genome analyses, including chromosome painting in over 40 diverse mammalian species, ordered gene maps from several representatives of different mammalian and vertebrate orders, and large-scale sequencing of the human and mouse genomes are beginning to provide insight into the rates and patterns of chromosomal evolution on a whole-genome scale, as well as into the forces that have sculpted the genomes of extant mammalian species.