Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Tau and transgenic animal models.

¹Division of Psychiatry Research, University of Zürich, August Forel Strasse 1, 8008, Zürich, Switzerland. goetz@bli.unizh.ch

Brain Research. Brain Research Reviews

|June 26, 2001

Summary

Genetic and transgenic studies reveal tau protein dysfunction can cause neurodegeneration and dementia, similar to Alzheimer's disease (AD). Animal models help assess therapies for tauopathies and AD, exploring the link between Abeta and tau pathology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MRI for Mixing Quality in Microfluidics.

Magnetic resonance in chemistry : MRC·2026

Same author

[Injection treatment for cervical and lumbar syndromes: principles, indications and general performance].

Orthopadie (Heidelberg, Germany)·2023

Same author

[Bed capacity analysis for an intensive care unit : Retrospective analysis and projection for need of intensive care beds in over 65 year olds with selected cardiovascular diseases].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2020

Same author

[Acute iron poisoning : Successful treatment of a potentially fatal suicidal attempt].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2018

Same author

[Ankle cartilage repair : Therapeutic options, results and technical aspects].

Der Orthopade·2017

Same author

[Orthoses and assistive devices in rheumatology : Prevention of disability, support of residual function].

Zeitschrift fur Rheumatologie·2017

Area of Science:

Neuroscience
Genetics
Pathology

Background:

Alzheimer's disease (AD) involves amyloid plaques and tau tangles.
Familial AD links to amyloid precursor protein (APP) mutations.
Tau dysfunction causes neurodegeneration in diseases like FTDP-17.

Purpose of the Study:

Review tau's cellular functions and FTDP-17.
Discuss advances in transgenic mouse models for tauopathies and AD.
Explore the relationship between Abeta production and tau pathology.

Main Methods:

Review of genetic and transgenic studies.
Analysis of animal models expressing tau, kinases, and phosphatases.
Examination of neuropathology and clinical syndromes.

Main Results:

Tau dysfunction, independent of Abeta, causes neurodegeneration.
Transgenic models link neurofibrillary tangles to neuronal loss.
Animal models offer platforms for therapeutic assessment.

Conclusions:

Tau pathology is a key factor in neurodegenerative diseases.
Transgenic models are crucial for understanding AD and tauopathies.
Further research can elucidate the Abeta-tau interaction in dementia.

Related Experiment Videos