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Human papillomavirus in conjunctival papilloma
N C Sjö1, S Heegaard, J U Prause
1Eye Pathology Institute, University of Copenhagen, Denmark.
The British Journal of Ophthalmology
|June 26, 2001
Summary
Human papillomavirus (HPV) is strongly linked to conjunctival papillomas, with HPV types 6/11 being the most prevalent. Koilocytosis is an unreliable indicator of HPV in these ocular tumors.
Area of Science:
- Ophthalmology
- Virology
- Oncology
Background:
- Conjunctival papillomas are benign epithelial tumors affecting the eye.
- The role of human papillomavirus (HPV) in their etiology is suspected but requires further investigation.
- Koilocytosis, a cytopathic effect, is often associated with HPV infections.
Purpose of the Study:
- To determine the prevalence of HPV in conjunctival papillomas.
- To identify specific HPV types involved in conjunctival papilloma development.
- To assess the diagnostic utility of koilocytosis as an indicator of HPV in these lesions.
Main Methods:
- Analysis of 55 archival conjunctival papilloma tissue samples.
- Detection of HPV DNA using polymerase chain reaction (PCR) and filter hybridization.
- Histopathological evaluation for the presence of koilocytosis.
Main Results:
- HPV was detected in 92% (48/52) of evaluable conjunctival papillomas.
- HPV types 6/11 were the most common, found in 40/47 cases.
- Koilocytosis was observed in 40% (22/55) of the papillomas.
Conclusions:
- A significant association exists between HPV infection and conjunctival papillomas.
- HPV types 6/11 are the predominant viral types implicated in these tumors.
- Koilocytosis demonstrates low sensitivity as a marker for HPV in conjunctival papillomas.