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Bacterial keratitis: a prospective clinical and microbiological study.
F Schaefer1, O Bruttin, L Zografos
1Jules Gonin Eye Hospital, University of Lausanne, Switzerland.
The British Journal of Ophthalmology
|June 26, 2001
Summary
This study analyzed bacterial keratitis cases, identifying common bacteria and risk factors. Fluoroquinolones are recommended, but in vitro resistance highlights the need for careful antibiotic selection in bacterial keratitis treatment.
Area of Science:
- Ophthalmology
- Microbiology
- Infectious Diseases
Background:
- Bacterial keratitis is a significant cause of vision loss.
- Understanding the local microbiological profile and antibiotic resistance patterns is crucial for effective treatment.
Purpose of the Study:
- To characterize the clinical and microbiological features of bacterial keratitis.
- To evaluate in vitro antibiotic resistance of bacterial isolates.
Main Methods:
- Prospective study of 85 bacterial keratitis patients.
- Clinical data collection including risk factors and visual acuity.
- Bacteriological analysis and antibiotic susceptibility testing using NCCLS disc diffusion.
Main Results:
- Common risk factors included contact lens wear (36%), blepharitis (21%), and trauma (20%).
- Predominant bacteria: Staphylococcus epidermidis (40%), Staphylococcus aureus (22%), Streptococcus pneumoniae (8%).
- Significant in vitro resistance observed: polymyxin B (54%), fusidic acid (51%), bacitracin (45%).
Conclusions:
- Fluoroquinolones are suggested as first-line therapy for bacterial keratitis.
- In vitro resistance necessitates monitoring and consideration of alternative antibiotics.