Related Experiment Video
Updated: Jun 30, 2026

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
Published on: February 19, 2019
The epidemic behavior of the hepatitis C virus
O G Pybus1, M A Charleston, S Gupta
1Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK. oliver.pybus@zoo.ox.ac.uk
Abstract:
Hepatitis C virus (HCV) is a leading worldwide cause of liver disease. Here, we use a new model of HCV spread to investigate the epidemic behavior of the virus and to estimate its basic reproductive number from gene sequence data. We find significant differences in epidemic behavior among HCV subtypes and suggest that these differences are largely the result of subtype-specific transmission patterns. Our model builds a bridge between the disciplines of population genetics and mathematical epidemiology by using pathogen gene sequences to infer the population dynamic history of an infectious disease.
Related Concept Videos
Viral Recombination
Infectious Diseases and Their Occurrence
Yellow Fever
Hepatitis
Amebiasis
Viral Hepatitis I: Introduction

