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Monocyte tissue factor levels in cancer patients
B A Lwaleed1, J L Francis, M Chisholm
1University Department of Haematology Level F (827), South Academic Block, Southampton University Hospital, Tremona Road, Southampton, SO16 6YD, United Kingdom. njasser@ksu.edu.sa
Saudi Medical Journal
|June 26, 2001
Summary
Monocyte tissue factor levels, measured after lipopolysaccharide stimulation, show promise in detecting cancer and monitoring tumor progression. This assay can help identify individuals at high risk for cancer development.
Area of Science:
- Oncology
- Hematology
- Biochemistry
Background:
- The link between cancer and thromboembolic disease is well-established, with increased tissue factor expression by monocytes implicated.
- Monocyte tissue factor levels may serve as a biomarker for cancer presence and progression.
Purpose of the Study:
- To evaluate the diagnostic and prognostic utility of monocyte tissue factor measurements in various cancers.
- To assess the sensitivity and specificity of a lipopolysaccharide-stimulated monocyte tissue factor assay for cancer detection.
Main Methods:
- A kinetic chromogenic assay was used to measure monocyte tissue factor levels in normal controls, patient controls, and patients with benign and malignant diseases of the bladder, prostate, breast, and colorectum.
- Measurements were taken from both baseline (resting) and lipopolysaccharide-stimulated monocytes.
- Benign disease groups were further categorized into inflammatory and non-inflammatory subtypes.
Main Results:
- The lipopolysaccharide-stimulated monocyte tissue factor assay demonstrated sensitivity and specificity for cancer detection (AUC=0.71).
- Malignant groups exhibited significantly higher monocyte tissue factor levels compared to control and benign non-inflammatory groups.
- Monocyte tissue factor levels correlated with tumor grade, stage, survival, PSA levels, and bone scan findings, and were elevated in cases of bladder cancer recurrence and mortality.
Conclusions:
- Lipopolysaccharide-stimulated monocyte tissue factor assays show potential for cancer detection and distinguishing between malignant and non-inflammatory conditions.
- Monocyte tissue factor levels are elevated in malignant and benign inflammatory conditions, but not significantly different between malignant and benign inflammatory groups.
- This assay may aid in identifying high-risk individuals and monitoring cancer progression.