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Flexible two-stage designs: an overview
1Department of Medical Statistics, University of Vienna. peter.bauer@univie.ac.at
Methods of Information in Medicine
|June 27, 2001
Abstract:
In this overview we introduce the basic ideas behind a new flexible approach in sequential designs. The different concepts based on two-stage combination tests and conditional error functions are brought together. We sketch the construction of p-values, confidence intervals, and median unbiased estimates. Finally, recursive combination tests are introduced which extend the flexibility to the choice of the number of interim analyses.