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Related Experiment Videos

[Specific bronchial provocation test with solid aerosols. Quantification of results].

D Choudat1, J C Martin, J F Fabries

  • 1Service de pathologie professionnelle, Centre hospitalier universitaire Cochin, AP-HP-Université Paris V, 27 rue du Faubourg Saint Jacques, 75014, Paris. dominique.choudat@cch.ap-hop-paris.fr

Revue Des Maladies Respiratoires
|June 27, 2001
PubMed
Summary

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Occupational asthma from flour exposure can be assessed using bronchial challenge tests. A new method helps identify moderate reactivity in asthmatic subjects by comparing flour and lactose challenges.

Area of Science:

  • Occupational Medicine
  • Pulmonology
  • Allergy and Immunology

Background:

  • Occupational asthma is a significant health concern for individuals exposed to airborne allergens like wheat flour.
  • Assessing specific bronchial reactivity is crucial for diagnosing and managing occupational asthma.

Purpose of the Study:

  • To determine the level of specific bronchial reactivity to flour in asthmatic subjects.
  • To establish criteria for positivity in bronchial challenge testing using a novel method for result expression.

Main Methods:

  • Thirty-eight asthmatic subjects occupationally exposed to wheat flour underwent challenge testing with lactose and then flour.
  • Inhaled dose and dose-response relationships were calculated using instantaneous measurements of airflow and concentration.

Related Experiment Videos

  • Results were analyzed by the dose of flour causing a 20% fall in FEV1 (PDf20) and by comparing FEV1 variations to lactose challenge data.

    • Main Results:

    • Flour challenge revealed three groups: high reactivity (n=15, >20% FEV1 fall), moderate reactivity (n=10, significant FEV1 fall but <20%), and non-significant reactivity (n=13).
    • Lactose challenge showed no significant relationship between FEV1 variation and inhaled lactose dose.
    • For moderate reactivity, the inhaled dose rate appeared to influence bronchial response.

    Conclusions:

    • PDf20 effectively measures specific bronchial reactivity to flour.
    • Comparing flour and lactose challenges aids in detecting moderate reactivity when FEV1 fall is <20%.
    • Inhaled dose and dose rate are important factors in the development of bronchial obstruction in asthmatic subjects.