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Updated: Feb 11, 2026

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[Pre- and post-natal corticosteroids: side effects].

G Buonocore1, S Perrone, L De Marco

  • 1Instituto di Pediatria Preventiva e Neonatologia, Università degli Studi di Siena. buonocore@unisi.it

Acta Bio-Medica De L'Ateneo Parmense : Organo Della Societa Di Medicina E Scienze Naturali Di Parma
|June 27, 2001
PubMed
Summary
This summary is machine-generated.

Prenatal steroid therapy (ST) benefits premature infants, but repeated courses raise safety concerns. Animal and human studies suggest potential adverse effects on development and increased risks for mothers and newborns.

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Area of Science:

  • Neonatal Medicine
  • Pharmacology
  • Developmental Biology

Context:

  • Prenatal steroid therapy (ST) is established for reducing mortality and morbidity in premature infants.
  • Concerns exist regarding the safety and efficacy of repeated antenatal ST courses.
  • Potential adverse effects on maternal and infant health necessitate further investigation.

Purpose:

  • To review the known benefits and potential risks of antenatal steroid therapy (ST) in premature infants.
  • To evaluate the safety and efficacy of repeated courses of ST.
  • To identify knowledge gaps and areas for future research.

Summary:

  • Single courses of antenatal ST are beneficial for premature infants, reducing respiratory distress syndrome and intraventricular hemorrhage.
  • Repeated courses of antenatal ST in animals show adverse effects on lung, brain, and adrenal development.
  • Human studies link multiple ST courses to smaller head circumference and increased maternal/neonatal infections, with postnatal ST showing acute side effects without improving mortality.

Impact:

  • Highlights the risks associated with repeated antenatal steroid therapy, challenging its widespread use.
  • Underscores the need for cautious application of ST and further research into optimal dosing and timing.
  • Emphasizes the critical lack of long-term follow-up data, necessitating prospective trials to clarify risks and benefits.