Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sex-linked familial reflux.

G W Middleton, S S Howards, J Y Gillenwater

    The Journal of Urology
    |July 1, 1975
    PubMed
    Summary

    This study describes a family with vesicoureteral reflux (VUR) primarily affecting males, suggesting X-linked inheritance. However, most familial VUR cases follow multifactorial inheritance patterns, requiring further research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The impact of the immunological context on outcomes of solid cancer patients treated with genotype-matched targeted therapies: a comprehensive review.

    Annals of oncology : official journal of the European Society for Medical Oncology·2025
    Same author

    Bevacizumab with peri-operative epirubicin, cisplatin and capecitabine (ECX) in localised gastro-oesophageal adenocarcinoma: a safety report.

    Annals of oncology : official journal of the European Society for Medical Oncology·2012
    Same author

    Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer.

    Expert review of vaccines·2010
    Same author

    SpermCheck Fertility, an immunodiagnostic home test that detects normozoospermia and severe oligozoospermia.

    Human reproduction (Oxford, England)·2010
    Same author

    Combined analysis of two multicenter studies of finasteride 5 mg in the treatment of symptomatic benign prostatic hyperplasia.

    Prostate cancer and prostatic diseases·2002
    Same author

    Gamete retrieval in terminal conditions.

    American journal of obstetrics and gynecology·2001

    Area of Science:

    • Genetics
    • Urology
    • Pediatrics

    Background:

    • Vesicoureteral reflux (VUR) is a common congenital anomaly in children.
    • The inheritance pattern of familial VUR is complex and not fully understood.
    • Previous studies suggest multifactorial polygenic inheritance for most familial VUR cases.

    Purpose of the Study:

    • To describe a unique family pedigree with a high prevalence of VUR in males.
    • To investigate the potential mode of genetic transmission in this specific family.
    • To contribute to the understanding of VUR inheritance patterns.

    Main Methods:

    • Pedigree analysis of a multigenerational family.
    • Clinical evaluation of affected and unaffected family members.
    • Review of existing literature on VUR inheritance.

    Main Results:

    • VUR was observed in 3 brothers and the maternal grandfather.
    • The father, mother, and 3 daughters were urologically normal.
    • The observed pattern strongly suggests X-linked genetic transmission in this family.

    Conclusions:

    • The described pedigree presents a potential case of X-linked VUR.
    • This finding contrasts with the generally accepted multifactorial polygenic inheritance of familial VUR.
    • Further extensive studies of VUR pedigrees are necessary to establish definitive inheritance patterns.

    Related Experiment Videos