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Published on: September 12, 2014
Genomewide survey of panic disorder.
R R Crowe1, R Goedken, S Samuelson
1Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242-1000, USA. ray-crowe@uiowa.edu
American Journal of Medical Genetics
|June 27, 2001
Summary
This study identified a potential genetic linkage for panic disorder on chromosome 7p. Further research is needed to confirm this finding and understand its implications for panic disorder genetics.
Area of Science:
- Genetics
- Psychiatry
- Genomic Research
Background:
- Panic disorder is a complex psychiatric condition with a significant genetic component.
- Previous genetic studies have suggested potential linkage regions, but definitive loci remain elusive.
Purpose of the Study:
- To conduct a genome-wide scan to identify genetic loci associated with panic disorder.
- To refine the location of potential susceptibility genes for panic disorder.
Main Methods:
- Genome scan of 23 multiplex families with panic disorder using 469 genetic markers.
- Calculation of two-point lod scores and construction of lod score maps.
- Nonparametric multipoint analysis using GENEHUNTER.
Main Results:
- Lod scores < -2.00 across 94-95% of the genome, indicating widespread exclusion.
- The highest lod score of 2.23 was observed at the D7S2846 locus on chromosome 7.
- Nonparametric analysis yielded an NPL score of 2.97 in a region on chromosome 7p, consistent with previous findings.
Conclusions:
- The study provides evidence for linkage of panic disorder to a specific region on chromosome 7p.
- This region is a promising candidate for further investigation into the genetic basis of panic disorder.
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