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Risk factors for benign breast biopsies: a nested case-control study in the Alberta breast screening program
C M Friedenreich1, H E Bryant, F Alexander
1Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, Calgary.
Cancer Detection and Prevention
|June 27, 2001
Summary
Current cigarette smoking significantly increases the risk of benign breast biopsies. However, regular alcohol consumption and certain physical activities may reduce this risk, offering insights for breast screening programs.
Area of Science:
- Oncology
- Epidemiology
- Radiology
Background:
- Benign breast biopsies are common following mammogram abnormalities.
- Identifying risk factors for benign biopsies can refine screening protocols.
Purpose of the Study:
- To investigate lifestyle risk factors associated with benign breast biopsies.
- To assess the role of smoking, alcohol consumption, and physical activity in benign breast biopsy outcomes.
Main Methods:
- A nested case-control study design was employed.
- 382 cases with benign breast biopsies and 399 controls without biopsies were analyzed.
- Risk factors including smoking, alcohol use, and physical activity were assessed.
Main Results:
- Current cigarette smoking showed a 2.04-fold increased risk for benign breast biopsies.
- Ever regular smoking (1.61-fold) and passive smoking (1.41-fold) also increased risk.
- Ever alcohol consumption (0.61-fold) and higher levels of physical activity demonstrated risk reduction.
Conclusions:
- Lifestyle factors, particularly smoking, are linked to benign breast biopsies.
- Alcohol consumption and physical activity may offer protective effects.
- Understanding these factors can help optimize breast screening and reduce unnecessary biopsies.