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Genomic multi-level nutrient-sensing pathways.

M A Brudnak1

  • 1MAK Wood, Inc., P.O. Box 184 Thiensville, WI 53092, USA. makwood@earthlink.net

Medical Hypotheses
|June 27, 2001
PubMed
Summary

Nutritional supplements, termed genomeceuticals, can target the genome to alter gene expression and function. Glucosamine, for example, up-regulates the obese (ob) gene by influencing nutrient-sensing pathways.

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Area of Science:

  • Nutritional genomics
  • Pharmacogenomics
  • Biochemistry

Background:

  • Pharmaceutical and natural product industries traditionally target biochemical or cellular pathways.
  • The genome represents a largely untapped area for therapeutic and supplement development.
  • Nutritional interventions can potentially influence genetic integrity, expression, and fidelity.

Purpose of the Study:

  • To explore the potential of nutrients targeting the genome, termed 'genomeceuticals'.
  • To introduce the concept of exploiting nutrient-sensing pathways at the genetic level.
  • To discuss how genomeceuticals can modulate gene products and their functions.

Main Methods:

  • Literature review and conceptual framework development.
  • Analysis of nutrient-gene interactions.
  • Exploration of 'nutrient-sensing' pathways.

Main Results:

  • Identified glucosamine as a compound that up-regulates the obese (ob) gene.
  • Demonstrated glucosamine's action via a 'nutrient-sensing' pathway.
  • Proposed a model for exploiting genetic nutrient-sensing pathways.

Conclusions:

  • Genomeceuticals offer a novel approach to health and disease management by targeting genetic pathways.
  • Nutrient-sensing pathways can be modulated to alter gene expression and function.
  • This approach extends beyond replacing deficient substances to actively modifying genomic output.

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