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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...

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Related Experiment Video

Updated: Jun 18, 2026

Murine Skin Transplantation
06:42

Murine Skin Transplantation

Published on: January 16, 2008

Advances in transplantation tolerance.

X Yu1, P Carpenter, C Anasetti

  • 1Human Immunogenetics Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Lancet (London, England)
|June 27, 2001
PubMed
Summary
This summary is machine-generated.

Current immunosuppressive drugs improve organ transplant survival but do not induce tolerance. New strategies targeting T-cell death and inactivation are crucial for achieving long-term transplantation tolerance.

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18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

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Last Updated: Jun 18, 2026

Murine Skin Transplantation
06:42

Murine Skin Transplantation

Published on: January 16, 2008

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Area of Science:

  • Immunology
  • Transplantation Science

Background:

  • Organ allograft survival has improved with recent immunosuppressive drugs, yet lifelong medication is still required.
  • Graft rejection involves T-cell activation, antigen recognition, and accessory signaling, with T-cell death being a key tolerance mechanism.

Purpose of the Study:

  • To explore how different immunosuppressive drugs impact T-cell mediated transplantation tolerance.
  • To differentiate between drugs that inhibit tolerance by preventing T-cell death and those that promote it.

Main Methods:

  • Analysis of T-cell activation, antigen recognition, and accessory signaling pathways.
  • Evaluation of drug effects on T-cell death (apoptosis) and T-cell unresponsiveness (anergy).

Main Results:

  • Drugs like mycophenolate mofetil, which induce T-cell death, may facilitate tolerance.
  • Inhibiting T-cell division (e.g., with rapamycin) or costimulation (e.g., blocking CD28/CD154) can lead to T-cell unresponsiveness and promote tolerance.

Conclusions:

  • Understanding T-cell death and inactivation mechanisms is vital for developing strategies to achieve transplantation tolerance.
  • Targeting specific T-cell pathways offers a promising avenue beyond current immunosuppression for long-term graft acceptance.