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Anticonvulsant effects of new morphinan derivatives
H C Kim1, T Nabeshima, W K Jhoo
1Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, 200-701, Chunchon, South Korea. kimhc@cc.kangwon.ac.kr
Bioorganic & Medicinal Chemistry Letters
|June 27, 2001
Abstract:
We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.