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Novel sulfonate derivatives: potent antimitotic agents
S L Gwaltney1, H M Imade, Q Li
1Cancer Research, D47B, Building AP-10, Abbott Laboratories, 60064-6101, Abbott Park, IL, USA
Bioorganic & Medicinal Chemistry Letters
|June 27, 2001
Abstract:
The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.