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Ethambutol analogues as potential antimycobacterial agents
H Häusler1, R P Kawakami, E Mlaker
1Glycogroup, Institut für Organische Chemie der Technischen Universität Graz, Stremayrgasse 16, A-8010, Graz, Austria.
Bioorganic & Medicinal Chemistry Letters
|June 27, 2001
Abstract:
A range of new ethambutol analogues was synthesised and their inhibitory potencies were probed with Mycobacterium smegmatis. Interestingly, apparently even minor deviation from the structure of the parent compound resulted in reduced antimycobacterial activity.