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Updated: Aug 10, 2026

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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Parallel-stranded hairpins containing 8-aminopurines. Novel efficient probes for triple-helix formation
A Aviñó1, J C Morales, M Frieden
1Cygene Spain S.L., Parc Científic de Barcelona, Baldiri i Reixac, 10-12, E-08028, Barcelona, Spain.
Bioorganic & Medicinal Chemistry Letters
|June 27, 2001
Abstract:
We describe novel oligomers with a greater propensity to form triplexes than oligomers containing only natural bases. They consist of a polypyrimidine sequence linked head-to-head with a polypurine sequence carrying one or several 8-aminoadenine or 8-aminoguanines. The presence of 8-aminopurines also stabilised the parallel-stranded duplex structure.
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