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Related Experiment Videos

Temperature effect on nausea during fluorescein angiography.

L R Lee1, D P Hainsworth, C W Hamm

  • 1Mason Eye Institute, University of Missouri, Columbia, Missouri 65212, USA.

Ophthalmology
|June 27, 2001
PubMed
Summary

Warming fluorescein dye before fluorescein angiography (FA) does not reduce nausea. This study found no significant difference in nausea frequency between patients receiving room temperature or body temperature dye.

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Area of Science:

  • Ophthalmology
  • Clinical Trials
  • Patient Safety

Background:

  • Nausea is a common adverse effect of fluorescein angiography (FA).
  • Anecdotal reports suggest warming fluorescein dye may reduce nausea.
  • The efficacy of prewarming fluorescein dye for FA has not been rigorously evaluated.

Purpose of the Study:

  • To investigate the effect of prewarming fluorescein dye to body temperature on the frequency of nausea and other adverse effects during FA.

Main Methods:

  • Prospective, randomized, controlled trial involving 547 angiograms in 394 patients.
  • Patients were assigned to receive either room temperature dye (control) or body temperature dye (study).
  • Patients were masked to dye temperature and questioned about adverse effects post-procedure.

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Main Results:

  • Overall adverse reactions occurred in 7.1% of procedures, with nausea reported in 5.9%.
  • No statistically significant difference in the frequency of adverse reactions or nausea was observed between the warmed dye group and the control group (P = 0.41 and P = 0.28, respectively).
  • The study was powered to detect a clinically significant difference of 4-10% between groups.

Conclusions:

  • Warming fluorescein dye to body temperature does not significantly reduce the incidence of nausea associated with fluorescein angiography.
  • Prewarming fluorescein dye is not an effective strategy for mitigating nausea in patients undergoing FA.