Related Experiment Video
Updated: Oct 5, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Viral levels in newborn African infants undergoing primary HIV-1 infection
R J Biggar1, R Broadhead, M Janes
1Viral Epidemiology Branch, NCI, Bethesda, Maryland, USA.
Abstract:
We examined weekly changes in viral levels in seven untreated infants infected with HIV at birth. Viral levels spiked immediately but reverted quickly to plateau levels typical of infant HIV infection within 2 weeks of first detected viraemia. We speculated that the depletion of naive, susceptible cells is responsible for the rapid decrease in spike levels and that the rapid replacement of lymphocytes in infants causes the high plateau viral levels (10(5) copies/ml) to be sustained.
Related Concept Videos
Cytomegalovirus Disease
Human Virome

