Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulation of polymorphonuclear leukocyte function by platelets.

K A Aziz1, M Zuzel

  • 1Department of Hematology, The University of Liverpool, Liverpool, United Kingdom.

Saudi Medical Journal
|June 27, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells.

Leukemia·2005
Same author

In vitro procoagulant and anticoagulant properties of Naja naja naja venom.

Toxicon : official journal of the International Society on Toxinology·2003
Same author

The biology of hairy cells.

Best practice & research. Clinical haematology·2003
Same author

The inhibition of platelet aggregation and blood coagulation by Micropechis ikaheka venom.

British journal of haematology·2001
Same author

CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia.

Blood·2001
Same author

Activation-dependent proteolytic degradation of polymorphonuclear CD11b.

British journal of haematology·2000
Same journal

Molecular Mechanisms of Diffuse Large B-Cell Lymphoma and the Complexities of Tumor Development.

Saudi medical journal·2026
Same journal

Polysomnographic and Clinical Characteristics of Narcolepsy in Saudi Arabia: <i>A 12-Year Retrospective Study</i>.

Saudi medical journal·2026
Same journal

Etiology, Management, and Outcomes of Hospitalized Heart Failure Patients: <i>A Single-Center Study</i>.

Saudi medical journal·2026
Same journal

Effect of Anesthetic Agents on Middle Ear Pressure: Systematic Review and Meta-Analysis.

Saudi medical journal·2026
Same journal

Evaluation of Raqeem Health Information System in Primary Healthcare Centers in Makkah, Saudi Arabia, Using the DeLone and McLean Information System Success Model.

Saudi medical journal·2026
Same journal

Integrating Traditional and Complementary Medicine into Saudi Primary Care: <i>A Literature Review in Light of the WHO 2025-2034 Strategy</i>.

Saudi medical journal·2026
See all related articles

Platelet compounds modulate neutrophil functions, sometimes enhancing, sometimes inhibiting oxidant production. Platelet constituents also consistently boost neutrophil degranulation and migration, proving beneficial.

Area of Science:

  • Immunology
  • Hematology
  • Cell Biology

Background:

  • Platelets play a crucial role in hemostasis and thrombosis.
  • Platelets also interact with leukocytes, influencing immune responses.
  • The specific effects of platelet-derived factors on neutrophil function require further elucidation.

Purpose of the Study:

  • To comprehensively investigate the impact of platelet-derived constituents on key polymorphonuclear neutrophil leukocyte (PMN) functions.
  • To differentiate the effects of various platelet granule components on PMN responses.

Main Methods:

  • Isolation of polymorphonuclear neutrophil leukocytes (PMNs) and platelets from healthy volunteers.
  • Stimulation of platelets to release alpha- and/or dense granule contents.
  • Assessment of PMN oxidase activity, degranulation, and migration in response to platelet factors.

Related Experiment Videos

Main Results:

  • Platelet constituents exhibited time-dependent dual effects on PMN oxidant production: enhancement by dense granule nucleotides (ADP, ATP) and inhibition by AMP.
  • Inhibitory effects were reversed by granulocyte-macrophage colony-stimulating factor (GM-CSF).
  • Platelet alpha-granule components, likely Platelet Factor 4 (PF4), consistently enhanced PMN degranulation and migration.

Conclusions:

  • Platelets actively modulate PMN function through the release of granular constituents.
  • These modulations, including enhanced degranulation and migration, are physiologically advantageous.
  • Platelet-derived factors offer a complex regulatory mechanism impacting neutrophil immune activities.